产品详情
产品名称CLEC7A Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total CLEC7A protein.
免疫原类型Recombinant Protein
免疫原描述Full length fusion protein
基因/蛋白名称CLEC7A
标记Unconjugated
别名BGR; CANDF4; DECTIN1; CLECSF12
数据库入口号Swiss-Prot#: Q9BXN2
NCBI Gene ID: 64581
Gene Accssion: BC013385
Uniprot
Q9BXN2
实际分子量28kd
浓度0.2mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:10-1:50
Gel: 12%SDS-PAGE
Lysates (from left to right): SP20 and RAW264.7 cell
Amount of lysate: 40ug per lane
Primary antibody: 1/200 dilution
Secondary antibody dilution: 1/8000
Exposure time: 30 seconds
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using #35673 at dilution 1/5.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.
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et al,Spi1 aggravates neuropathic pain by modulating Clec7a-mediated neuroinflammation and microglial phagocytosis
, (2025),
PMID:
40640733
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