产品详情
产品名称PRMT7 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB
种属反应性Human
特异性The antibody detects endogenous levels of total PRMT7 protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to a region derived from internal residues of human Protein arginine methyltransferase 7
基因/蛋白名称PRMT7
标记Unconjugated
别名ANM7;FLJ10640;KIAA1933
数据库入口号Swiss-Prot#: Q9NVM4
NCBI Gene ID: 54496
Gene Accssion: BC000146
Uniprot
Q9NVM4
实际分子量78kd
浓度1.1mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-1:2000
Gel: 10%SDS-PAGE
Lysates (from left to right): Human liver cancer tissue
Amount of lysate: 50ug per lane
Primary antibody: 1/500 dilution
Secondary antibody dilution: 1/8000
Exposure time: 5 minutes
Protein arginine methyltransferase 7?is a?protein?that in humans is encoded by the?PRMT7?gene.?Arginine?methylation?is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using?S-adenosylmethionine?(AdoMet) as the methyl donor. Arginine methylation is implicated in?signal transduction, RNA transport, and?RNA splicing. May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT).
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et al,A novel 3-alkenylindol-2-one derivative selectively inhibits the growth of acute myeloid leukemia via modulation of the MYC-PRMT pathway
, (2025),
PMID:
40619015
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