产品详情
产品名称PTP4A2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total PTP4A2 protein.
免疫原类型Recombinant Protein
免疫原描述Fusion protein corresponding to residues near the N terminal of human protein tyrosine phosphatase type IVA, member 2
基因/蛋白名称PTP4A2
标记Unconjugated
别名HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
数据库入口号Swiss-Prot#: Q12974
NCBI Gene ID: 8073
Gene Accssion: BC070182
Uniprot
Q12974
实际分子量19kd
浓度0.8mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100
Gel: 10%SDS-PAGE
Lysates (from left to right): Hela, Jurkat and SKOV3 cell
Amount of lysate: 50ug per lane
Primary antibody: 1/300 dilution
Secondary antibody dilution: 1/8000
Exposure time: 30 seconds
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using #35892 at dilution 1/25.
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.
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et al,Collagen Hydrogel Loaded With 9-cisRA-Lip Is an Option for Treatment of Secondary Lymphedema after Surgery
, (2025),
PMID:
39611659
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