产品详情
产品名称DDR2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total DDR2 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human discoidin domain receptor tyrosine kinase 2
基因/蛋白名称DDR2
标记Unconjugated
别名TKT; MIG20a; NTRKR3; TYRO10
数据库入口号Swiss-Prot#: Q16832
NCBI Gene ID: 4921
Gene Accssion: NP_006173
Uniprot
Q16832
浓度1.6mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #37159 at dilution 1/40.
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain.?
如果您使用该产品37159发表了文章，请通知我们，让我们可以引用您的文献。
et al,Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth
, (2025),
PMID:
40759645
有货
