产品详情
产品名称PIK3C3 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total PIK3C3 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human phosphatidylinositol 3-kinase, catalytic subunit type 3
基因/蛋白名称PIK3C3
标记Unconjugated
别名VPS34; hVps34
数据库入口号Swiss-Prot#: Q8NEB9
NCBI Gene ID: 5289
Gene Accssion: NP_002638
Uniprot
Q8NEB9
浓度1.5mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using #37356 at dilution 1/40.
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using #37356 at dilution 1/40.
Phosphatidylinositol 3-kinase catalytic subunit type 3?is an?enzyme?that in humans is encoded by thePIK3C3?gene. PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation.
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et al,CSF-1R regulates non-small cell lung cancer cells dissemination through Wnt3a signaling.
, (2017),
PMID:
29218239
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