产品详情
产品名称HIST1H2AB Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total HIST1H2AB protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the C terminal of human histone cluster 1, H2ab
基因/蛋白名称HIST1H2AB
标记Unconjugated
别名H2A/m; H2AFM
数据库入口号Swiss-Prot#: P04908
NCBI Gene ID: 8335
Gene Accssion: NP_003504
Uniprot
P04908
实际分子量14kd
浓度1.5mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200
Gel: 10%SDS-PAGE
Lysates (from left to right): Hela, 231 and K562 cell,human fetal brain tissue
Amount of lysate: 40ug per lane
Primary antibody: 1/200 dilution
Secondary antibody dilution: 1/8000
Exposure time: 5 minutes
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using #37620 at dilution 1/20.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
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et al,DDTC-Cu (I) Nano-MOF Induces Ferroptosis by Targeting SLC7A11/GPX4 Signal in Colorectal Cancer
, (2025),
PMID:
40491359
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