产品详情
产品名称UBP1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human;Mouse
特异性The antibody detects endogenous levels of total UBP1 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from internal residues of human upstream binding protein 1
基因/蛋白名称UBP1
标记Unconjugated
别名LBP1A; LBP1B; LBP-1B; LBP-1a
数据库入口号Swiss-Prot#: Q9NZI7
NCBI Gene ID: 7342
Gene Accssion: NP_055332
Uniprot
Q9NZI7
浓度2.7mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:50-1:200
Immunohistochemical analysis of paraffin-embedded Human ovarain cancer tissue using #37699 at dilution 1/40.
LBP1 (Upstream-binding protein 1), also designated UBP1, LBP1A or LBP1B, is a 540 amino acid protein that belongs to the grh/CP2 family (grainyhead transcription factor family). LBP1 is a transcriptional activator that regulates the placental expression of CYP11A1 and activates the Hemoglobin globin promoter in erythroid cells. LBP1 is responsible for repressing transcription of HIV-1 by binding to and preventing TFIID from interacting with its promoter region. Null expression of LBP1 causes uterine growth retardation in mice embryos suggesting a critical role in extraembryonic angiogenesis. LBP1 localizes to the nucleus and is expressed in adrenal tissue, Hep G2, JEG-3, and HeLa cell lines. It forms two natural variants by alternative splicing. LBP1 can form homodimers as well as heterodimers with LBP-9. LBP-9 suppresses the expression of LBP1.
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et al,Gamma-aminobutyric acid-B receptor axis promotes proliferation and survival of multiple myeloma cells via enhancing ERK1/2 activity
, (2025),
PMID:
41243844
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