产品详情
产品名称TGFB1 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total TGFB1 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human TGFB1 (NP_000651.3).
基因/蛋白名称TGFB1
标记Unconjugated
别名TGFB1;CED;DPD1;LAP;TGFB;TGFbeta;TGF-��
数据库入口号Uniprot:P01137
GeneID:7040
Uniprot
P01137
Gene ID
7040
计算分子量44kDa
实际分子量12,25,45-65kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:1000 - 1:5000
IF/ICC 1:50 - 1:200
Western blot analysis of extracts from various cell lines using TGFB1 Rabbit Polyclonal Antibody.
Immunofluorescence analysis of NIH/3T3 cells using TGFB1 Rabbit Polyclonal Antibody.
Immunofluorescence analysis of Rat jejunum using TGFB1 Rabbit Polyclonal Antibody.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
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et al,Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions. In Drug Dev Res on 2022 Jun by Feng Wang, Jun Zhang,et al..PMID:35277868
, (2022),
PMID:
35277868
Yes
