产品详情
产品名称NF2 antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB
种属反应性Human
特异性The antibody detects endogenous level of total NF2 protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human NF2 (NP_000259.1).
基因/蛋白名称NF2
标记Unconjugated
别名NF2;ACN;BANF;SCH;merlin
数据库入口号Uniprot:P35240
GeneID:4771
Uniprot
P35240
Gene ID
4771
实际分子量70kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
Western blot analysis of extracts of various cell lines, using NF2 antibody.
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
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et al,PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth
, (2025),
PMID:
40132583
Yes
