产品详情
产品名称VPS4B Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total VPS4B protein.
免疫原类型Peptide
免疫原描述Synthetic peptide of human vacuolar protein sorting 4 homolog B (S. cerevisiae)
基因/蛋白名称VPS4B
标记Unconjugated
别名MIG1; SKD1; SKD1B; VPS4-2
数据库入口号Swiss-Prot:O75351
Gene Accssion:NP_004860
Uniprot
O75351
浓度1.2mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry:1:10-1:50
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #40402 at dilution 1/20.
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.
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et al,The skin hydration and anti‐ageing benefits of Ectoine, achieved through enhanced Src‐ERK‐mediated HAS‐2 and JNK‐driven AQP‐3 expression in human …
, (2025),
PMID:
41116229
Yes
