产品详情
产品名称CNTN1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用IHC WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total CNTN1 protein.
免疫原类型peptide
免疫原描述Synthetic peptide of human CNTN1
基因/蛋白名称CNTN1
标记Unconjugated
别名F3; GP135; MYPCN
数据库入口号Swiss-Prot#: Q12860
NCBI Gene ID: 1272
Uniprot
Q12860
计算分子量113kd
浓度1.5mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:500-2000
Immunohistochemistry: 1: 100-200
Gel: 6%SDS-PAGE
Lysate: 40 μg, Lane 1-5: Rat brain tissue£¬Mouse brain tissue£¬Human fetal brain tissue£¬Human cerebrum tissue£¬Human cerebella tissue lysates,
Primary antibody:CNTN1 antibody at dilution 1/550,
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
Exposure time: 10 seconds
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using CNTN1 Antibody at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CNTN1 Antibody at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: x200)
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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et al,Expression of Cntn1 is regulated by stress and associated with anxiety and depression phenotypes. In Brain Behav Immun on 2021 Jul by Songji Li, Wenyu Cao,
et al..PMID:33737174
, (2021),
PMID:
33737174
et al,CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in MiceInNeurotox ResOn2023 AugbyLinxuan Zhang?#?1,?Zehao Zeng et al..PMID:?37014368
, (2023),
PMID:
37014368
et al,CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and AstrocytesInAging DisOn2023 Oct 1bySong-Ji Li?1?2?3,?Min-Hui Ma et al..PMID: 37196127
, (2023),
PMID:
37196127
et al,Astrocyte-derived factors regulate CNS myelination. In Glia on 2024 Nov by Sybille Seiler, Franziska Rudolf,et al..PMID:39092473
, (2024),
PMID:
39092473
Yes
