产品详情
产品名称KCNH1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用IHC
种属反应性Human
特异性The antibody detects endogenous levels of total KCNH1 protein.
免疫原类型peptide
免疫原描述Synthetic peptide of human KCNH1
基因/蛋白名称KCNH1
标记Unconjugated
别名EAG; EAG1; TMBTS; h-eag; Kv10.1
数据库入口号Swiss-Prot#: O95259
NCBI Gene ID: 3756
Uniprot
O95259
浓度0.2mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Immunohistochemistry: 1: 20-100
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using KCNH1 Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using KCNH1 Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200)
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
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et al,Overexpression of CX3CL1-CX3CR1 Signaling in the Stria Vascularis Rather Than the Basilar Membrane may be the trigger for inflammaging in the Cochlea
, (2025),
PMID:
40058359
Yes
