产品详情
产品名称CNGA4 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification
应用WB
种属反应性Human
特异性The antibody detects endogenous levels of total CNGA4 protein.
免疫原类型peptide
免疫原描述Synthetic peptide corresponding to residues near the C terminal of human CNGA4
基因/蛋白名称CNGA4
标记Unconjugated
别名CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA
数据库入口号Swiss-Prot:Q8IV77
NCBI Gene ID:1262
NCBI Protein:NP_001032406
Uniprot
Q8IV77
计算分子量66 kDa
浓度0.7mg/ml
配方Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
保存Store at -20˚C
应用详情
Western blotting: 1:200-1:1000
Gel: 8%SDS-PAGE
lysate: 40 ¦Ìg, Lane 1-2: Human cerebella tissue and Human cerebrum tissue lysates,
Primary antibody: 46522£¨CNGA4 Antibody) at dilution 1/300
Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,
Exposure time: 5 seconds
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
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et al,Neuron–non‐neuron electrical coupling networks are involved in chronic stress‐induced electrophysiological changes in lateral habenular neurons
, (2025),
PMID:
40168081
Yes
