产品详情
产品名称Bcl-2 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Peptide affinity purified
应用WB;ICC;;IHC;FC
种属反应性Human
免疫原描述Synthetic peptide (KLH-coupled) within human Bcl-2 aa 20-80.
标记Unconjugated
别名Apoptosis regulator Bcl 2 antibody
Apoptosis regulator Bcl-2 antibody
Apoptosis regulator Bcl2 antibody
AW986256 antibody
B cell CLL/lymphoma 2 antibody
B cell leukemia/lymphoma 2 antibody
Bcl-2 antibody
Bcl2 antibody
BCL2_HUMAN antibody
C430015F12Rik antibody
D630044D05Rik antibody
D830018M01Rik antibody
Leukemia/lymphoma, B-cell, 2 antibody
Oncogene B-cell leukemia 2 antibody
PPP1R50 antibody
Protein phosphatase 1, regulatory subunit 50 antibody
数据库入口号Swiss-Prot#:P10415
Uniprot
P10415
计算分子量26kDa
实际分子量26kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB 1:500-1:2000;
IHC 1:50-1:200;
ICC 1:50-1:200;
FC: 1:50-1:100
Western blot analysis of extracts from 293T, Hela and HL-60 cells using BCL-2 Antibody.
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using Bcl-2 Antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using Bcl-2 Antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human stomach tissue using Bcl-2 Antibody.
Immunohistochemistry of paraffin-embedded human liver cancer using Bcl-2 Antibody at dilution of 1:200 (40x lens).
Immunofluorescence analysis of methanol-fixed Hela cells (green) using Bcl-2 Antibody.
Immunofluorescence analysis of methanol-fixed A549 cells using Bcl-2 Antibody.
Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments. Antibodies to Bcl-2 can be used with immunohistochemistry to identify cells containing the antigen. In healthy tissue, these antibodies will react with B-cells in the mantle zone, as well as some T-cells. However, there is a considerable increase in positive cells in follicular lymphoma, as well as many other forms of cancer. In some cases, the presence or absence of Bcl-2 staining in biopsies may be significant for the patient's prognosis or likelihood of relapse.
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et al,5鈥慛itro锟?锟?3鈥憄henylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway. In Int J Mol Med on 2021 Apr by Lingzhi Niu, Xin Liu,et al..PMID:33604681
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et al,Neferine, a novel ROCK1-targeting inhibitor, blocks EMT process and induces apoptosis in non-small cell lung cancer. In J Cancer Res Clin Oncol on 2022 Aug 19
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PMID:
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