产品详情
产品名称E Cadherin Rabbit mAb
来源种属Recombinant Rabbit
克隆性Monoclonal antibody
亚型Rabbit IgG
纯化Affinity-chromatography
应用WB;IHC;ICC/IF;FC
种属反应性Human
免疫原描述A synthesized peptide derived from human E Cadherin
基因/蛋白名称CDH1
标记Unconjugated
别名Arc1;Cadherin 1;CAM 120/80;CD324;CDHE;E-Cad/CTF3;ECAD;Epithelial cadherin ;LCAM;Uvomorulin;CDH1
数据库入口号P12830
Uniprot
P12830
计算分子量97 kDa
实际分子量135 kDa
配方Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
保存Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle.
应用详情
WB 1:1000-1:5000
IHC 1:100-1:200
ICC/IF 1:50-1:200
FC 1:20-1:100
Western Blot analysis of 293 cells using E-cadherin Polyclonal Antibody diluted at 1:2000
Western Blot analysis of HeLa cells using E-cadherin Polyclonal Antibody diluted at 1:2000
Cadherins comprise a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Members of this family of adhesion proteins include rat cadherin K (and its human homolog, cadherin-6), R-cadherin, B-cadherin, E/P cadherin and cadherin-5. The classical cadherins, E-, N- and P-cadherin, consist of large extracellular domains characterized by a series of five homologous NH2 terminal repeats. The most distal of these cadherins is thought to be responsible for binding specificity, transmembrane domains and carboxy terminal intracellular domains. The relatively short intracellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function.
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et al,PD-L1 Expression Is Regulated By NF-κB DurIng EMT SignalIng In Gastric CarcInoma. In Onco Targets Ther on 2019 Nov 25 by Xu D, Li J, et al..PMID:31819504
, (2019),
PMID:
31819504
Yes
