产品详情
产品名称FOXO4 Rabbit mAb
克隆号SD0817
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IHC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名AFX antibody AFX1 antibody Afxh antibody ALL1-fused gene from X chromosome antibody Fork head domain transcription factor AFX1 antibody Forkhead box O4 antibody Forkhead box protein O4 antibody FOXO 4 antibody Foxo4 antibody FOXO4_HUMAN antibody MGC117660 antibody MGC120490 antibody Mixed lineage leukemia, translocated to, 7 antibody MLLT7 antibody Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 antibody Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7 antibody RGD1561201 antibody
数据库入口号Swiss-Prot#:P98177
Uniprot
P98177
计算分子量54/48 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
IHC: 1:50-1:200
Western blot analysis of FOXO4 on human lung lysates using anti-FOXO4 antibody at 1/1,000 dilution.
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-FOXO4 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-FOXO4 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-FOXO4 antibody. Counter stained with hematoxylin.
FKHR (for forkhead in rhabdomyosarcoma), FKHRL1, and AFX1 are members of a subfamily of the forkhead family of transcription factors. AFX1, also known as FoxO4, is expressed in a wide variety of tissues and, like other FKHR proteins, AFX1 contains a single forkhead domain and serine-proline-rich region, which mediate DNA binding. AFX1-mediated transcriptional activation is regulated by the serine/threonine kinase Akt1, which phosphorylates AFX1 and in turn, sequesters AFX1 in the cytosol, thereby blocking nuclear localization and DNA binding. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. Additionally, the t(x;11) translocation of the AFX1 gene, which involves the fusion of a serine-proline-rich sequence of AFX1 to the carboxy terminus of a truncated MLL, results in acute lymphocytic leukemia.
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