产品详情
产品名称RON Rabbit mAb
克隆号SD2006
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, ICC/IF, IHC, IP, FC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名c met related tyrosine kinase antibody CD136 antibody CD136 antigen antibody CDw136 antibody Macrophage stimulating 1 receptor (c met related tyrosine kinase) antibody Macrophage stimulating 1 receptor antibody Macrophage stimulating protein receptor alpha chain antibody MACROPHAGE STIMULATING PROTEIN RECEPTOR antibody Macrophage stimulating protein receptor beta chain antibody Macrophage-Stimulating 1 Receptor (MST1R) antibody Macrophage-stimulating protein receptor beta chain antibody MSP receptor antibody Mst1r antibody MST1R variant RON30 antibody MST1R variant RON62 antibody NPCA3 antibody p185 RON antibody p185-Ron antibody Protein-tyrosine kinase 8 antibody PTK 8 antibody ptk8 antibody PTK8 protein tyrosine kinase 8 antibody Recepteur d��origine nantais (RON) antibody RON antibody RON protein tyrosine kinase antibody RON variant E2E3 antibody RON_HUMAN antibody Soluble RON variant 1 antibody Soluble RON variant 2 antibody Soluble RON variant 3 antibody Soluble RON variant 4 antibody Stem cell derived tyrosine kinase antibody
数据库入口号Swiss-Prot#:Q04912
Uniprot
Q04912
计算分子量185 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:200
ICC: 1:50-1:200
FC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-RON antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-RON antibody. Counter stained with hematoxylin.
ICC staining RON in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining RON in AGS cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining RON in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of THP-1 cells with RON antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
Receptor protein tyrosine kinases (PTKs) have been classified into different subclasses on the basis of sequence similarity and distinct structural characteristics. The c-Met encoded receptor represents the initial member of one class of receptors characterized by a heterodimeric structure and a cysteine-rich extracellular domain. Ron, also designated macrophage-stimulating protein receptor (MSP receptor), p185-Ron, CD136 antigen or PTK8 represents a second member of this receptor class. The intracellular PTK domains of Ron and Met are highly similar (63% sequence identity) while the extracellular domains are less related (25% sequence identity) and both are rich in cysteine residues. Mature Ron receptor is comprised of a disulfide-linked heterodimer formed from an alpha chain (Ron α) and a beta chain (Ron β). Proteolytic processing results in the separation of the N-terminal Ron α and C-terminal Ron β subunits.
如果您使用该产品49195发表了文章，请通知我们，让我们可以引用您的文献。
Yes
