产品详情
产品名称Pax2 Rabbit mAb
克隆号JJ082-08
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IHC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名FSGS7 antibody Paired box 2 antibody Paired box gene 2 antibody paired box homeotic gene 2 antibody paired box protein 2 antibody Paired box protein Pax 2 antibody Paired box protein Pax-2 antibody Paired box protein Pax2 antibody PAPRS antibody Pax 2 antibody
数据库入口号Swiss-Prot#:Q02962
Uniprot
Q02962
计算分子量45 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000
IHC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Pax2 antibody. Counter stained with hematoxylin.
Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. The PAX2 gene is expressed in primitive cells of the kidney, ureter, eye, ear, and central nervous system. More specifically, in human embryo sections, PAX2 is expressed in the optic vesicle and later in the retina, in the otic vesicle and later in the semicircular canals of the inner ear, and in mesonephros, metanephros, adrenals, spinal cord, and hindbrain. PAX2 mutations can be responsible for renal hypoplasia, either isolated or associated with various ophthalmologic manifestations ranging from retinal coloboma to microphthalmia. Lesions in the PAX6 gene accounts for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. PAX6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions.
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