产品详情
产品名称GLUT2 Rabbit mAb
克隆号JJ20-21
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB, IHC, FC
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名liver antibody Glucose Transporter 2 antibody Glucose Transporter GLUT2 antibody Glucose transporter type 2 antibody Glucose transporter type 2 liver antibody Glucose transporter, liver/islet antibody GLUT-2 antibody GLUT2 antibody GTR2_HUMAN antibody GTT2 antibody SLC2A2 antibody Solute carrier family 2 (facilitated glucose transporter) member 2 antibody Solute carrier family 2 facilitated glucose transporter member 2 antibody Solute carrier family 2, facilitated glucose transporter member 2 antibody
数据库入口号Swiss-Prot#:P11168
Uniprot
P11168
计算分子量57 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:1000
IHC: 1:50-1:200
FC: 1:50-1:100
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-GLUT2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kideny tissue using anti-GLUT2 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-GLUT2 antibody. Counter stained with hematoxylin.
Flow cytometric analysis of HepG2 cells with GLUT2 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody
Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. Glut1, Glut3 and Glut4 are high-affinity transporters, whereas Glut2 is a low-affinity transporter. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane and shows a much less dramatic translocation in response to insulin. Glut2 expression is seen in pancreatic beta cells, hepatocytes and basolateral membranes of intestinal and epithelial cells, while the highest expression of Glut3 has been found in neuronal tissue.
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