产品详情
产品名称Estrogen Receptor beta Rabbit mAb
克隆号JJ09-02
来源种属Recombinant Rabbit
克隆性 Monoclonal antibody
纯化ProA affinity purified
应用WB
种属反应性Human
免疫原描述recombinant protein
标记Unconjugated
别名ER BETA antibody ER-beta antibody Erb antibody ESR B antibody ESR BETA antibody ESR2 antibody ESR2_HUMAN antibody ESRB antibody ESTRB antibody estrogen nuclear receptor beta variant a antibody estrogen nuclear receptor beta variant b antibody estrogen receptor 2 (ER beta) antibody Estrogen receptor 2 antibody estrogen receptor beta 4 antibody Estrogen receptor beta antibody NR3A2 antibody Nuclear receptor subfamily 3 group A member 2 antibody
数据库入口号Swiss-Prot#:Q92731
Uniprot
Q92731
计算分子量59 kDa
配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:1,000-1:2,000
Western blot analysis of Estrogen Receptor beta on 293T cells lysates using anti-Estrogen Receptor beta antibody at 1/1,000 dilution.
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.
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