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GLO1 Rabbit mAb#49754

是否有货: Yes
产品详情

产品名称GLO1 Rabbit mAb

克隆号JU44-11

来源种属Recombinant Rabbit

克隆性 Monoclonal antibody

纯化ProA affinity purified

应用WB,ICC,IHC,FC

种属反应性Human;Mouse;Rat

免疫原描述Recombinant protein

标记Unconjugated

别名Aldoketomutase antibody
glo1 antibody
GLOD1 antibody
Glx I antibody
GLYI antibody
glyoxalase domain containing 1 antibody
Glyoxalase I antibody
Ketone aldehyde mutase antibody
Ketone-aldehyde mutase antibody
Lactoyl glutathione lyase antibody
Lactoylglutathione lyase antibody
LGUL_HUMAN antibody
Methylglyoxalase antibody
S D lactoylglutathione methylglyoxal lyase antibody
S-D-lactoylglutathione methylglyoxal lyase antibody

数据库入口号Swiss-Prot#:Q04760

Uniprot Q04760

计算分子量21 kDa

配方1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

保存Store at -20˚C

应用详情
WB: 1:500-1:2,000
IHC: 1:100-1:500
ICC: 1:100-1:500

FC: 1:50-1:100
Western blot analysis of GLO1 on different lysates using anti-GLO1 antibody at 1/500 dilution.
Positive control:
Lane 1: Mouse testis tissue
Lane 2: C2C12
Lane 3: 293
Lane 4: Rat spleen tissue
Immunohistochemical analysis of paraffin-embedded rat epididymis tissue using anti-GLO1 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human thyroid gland tissue using anti-GLO1 antibody. Counter stained with hematoxylin.
ICC staining GLO1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining GLO1 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining GLO1 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Flow cytometric analysis of Hela cells with GLO1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).
The glyoxal pathway plays a role in the detoxification of glucose degradation products (GDP). Glyoxalase I (GLO1), a member of the glyoxalase family, is effective in eliminating GDP. Overexpression or silencing of Glyoxalase I in mice brain suggests an association between Glyoxalase I and anxiety. Glyoxalase I has three isoforms generated from two alleles in the genome which forms two homodimers and one heterodimer, each subunit binding one zinc ion. Research demonstrates that GLO1 gene expression is induced in colon carcinoma. Both an insulin response element (IRE), and a zinc metal response element (MRE) in the promoter region of the GLO1 gene have been identified.

如果您使用该产品49754发表了文章,请通知我们,让我们可以引用您的文献。

et al,A lactate capture-sensing platform for facilitating early differential diagnosis of minimal change disease and focal segmental glomerulosclerosis in renal diseases , (2025),
PMID: 41192155

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk
;

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