产品详情
产品名称ADAM12 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC,IF
种属反应性Human;Mouse;Rat
免疫原描述Recombinant fusion protein of human ADAM12 (NP_067673.2).
标记Unconjugated
别名ADAM12;ADAM12-OT1;CAR10;MCMP;MCMPMltna;MLTN;MLTNA
数据库入口号Swiss Prot:O43184
GeneID:8038
Uniprot
O43184
计算分子量80kDa/99kDa
实际分子量100kDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200
Immunofluorescence analysis of C6 cells using ADAM12 at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of HeLa cells using ADAM12 at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of NIH/3T3 cells using ADAM12 at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using ADAM12 at 1:1000 dilution.
Immunohistochemistry of paraffin-embedded rat heart using ADAM12 at dilution of 1:100 (40x lens).
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form.
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et al,ADAM12 promotes temozolomide resistance in glioblastoma by activating the TNF-α-NF-κB pathway
, (2025),
PMID:
40180114
Yes
