产品详情
产品名称Cortactin Conjugated Antibody
来源种属Rabbit
克隆性Monoclonal
应用WB, IF, FC
种属反应性Hu, Ms, Rt
免疫原描述recombinant protein
标记AF荧光素
激发/发射波长AF350: 346nm/442nm
AF405: 401nm/421nm
AF488: 493nm/519nm
AF555: 555nm/565nm
AF594: 591nm/614nm
AF647: 651nm/667nm
AF680: 679nm/702nm
AF750: 749nm/775nm
别名Amplaxin antibody CTTN antibody EMS 1 antibody EMS1 antibody FLJ34459 antibody Mammary tumor and squamous cell carcinoma associated antibody Oncogene EMS1 antibody p80/85 src substrate antibody Src substrate cortactin antibody SRC8_HUMAN antibody
数据库入口号Swiss-Prot#:Q14247
Uniprot
Q14247
计算分子量75 kDa
配方0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide
保存Store at 4˚C in dark for 6 months
应用详情
WB: 1:50-1:200
IF:1:50-1:200
FC: 1:50-1:200
Cortactin (also designated Ems-1) is a filamentous Actin (F-Actin) binding protein that has been shown to be a substrate for Src p60. Cortactin contains tandem 37 amino acid repeats at the amino-terminus and an SH3 domain at the carboxy-terminus. The tandem repeats appear to be necessary for F-Actin binding. Tyrosine phosphorylation of Cortactin by Src p60 results in diminished F-Actin binding to Cortactin and reduced F-Actin cross-linking activity. Cortactin has also been shown to be phosphorylated in response to FGF-1. Cortactin exhibits abundant expression in megakaryocytes and platelets, and it may play a role in the maturation of megakaryocytes.
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et al,AURKA modulates tight junction functionality to influence the proliferation and metastasis of lung adenocarcinoma
, (2025),
PMID:
41201786
1-2 weeks
