产品详情
产品名称Mouse Granzyme B ELISA Kit
特异性Mouse
免疫原类型NSO,I21-S247
别名Granzyme B(G,H); 3.4.21.79; CTLA-1; Cytotoxic cell protease 1; CCP1; Fragmentin-2; Gzmb; Ctla-1, Ctla1;
数据库入口号P04187
Uniprot
P04187
应用详情
sensitivity:10pg ml
Detect Range:15.6pg ml-1000pg ml
sample_type:cell culture supernates cell lysates tissue homogenates serum and plasma (heparin EDTA).
capture_antibody:monoclonal antibody from rat
detection_antibody:polyclonal antibody from goat
gene_name:Gzmb
protein_name:Granzyme B(G H)
gene_full_name:Granzyme B(G H)
tissue_specificity:
sequence_similarities:
tmb_incubation:25-30min
research_category:
Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Granzyme B
protein_function: This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to belinked to an activation cascade of caspases (aspartate-specificcysteine proteases) responsible for apoptosis execution. Cleavescaspase-3, -7, -9 and 10 to give rise to active enzymes mediatingapoptosis (By similarity)..
Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface "nonself" antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
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et al,Filamentous phages as tumour-targeting immunotherapeutic bionanofibres
, (2025),
PMID:
39468354
1-2周
