产品详情
产品名称KDM1A(Phospho-Ser683) Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用Custom antibody
种属反应性Human;Mouse;Rat
免疫原类型Peptide-KLH
基因/蛋白名称KDM1A
标记Unconjugated
别名AOF2, KDM1, KIAA0601, LSD1
数据库入口号uniprot:O60341
计算分子量93kDa
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 128% glycerol.
保存Store at -20��C for long term preservation (recommended). Store at 4��C for short term use.
应用详情
Western blotting: 1:500~1:1000
Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:15620353, PubMed:15811342, PubMed:16140033, PubMed:16079794, PubMed:16079795, PubMed:16223729). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed (PubMed:15620353, PubMed:15811342, PubMed:16079794, PubMed:21300290). Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me (PubMed:15620353, PubMed:20389281, PubMed:21300290, PubMed:23721412).
如果您使用该产品SAB501P发表了文章，请通知我们，让我们可以引用您的文献。
et al,Wogonin modulates macrophage polarization and inflammatory signaling through the LSD1-p65 axis to alleviate osteoarthritis
, (2025),
PMID:
40818185
Yes
