免费电话:400-9961-933
邮箱:techcn@signalwayantibody.com
欢迎光临本站
登录 注册 English
位置: 首页 > 磷酸化抗体 > IGF-1R(Phospho-Tyr1165/Tyr1166) Antibody

IGF-1R(Phospho-Tyr1165/Tyr1166) Antibody#11088

IGF-1R(Phospho-Tyr1165/Tyr1166) Antibody
IGF-1R(Phospho-Tyr1165/Tyr1166) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称IGF-1R(Phospho-Tyr1165/Tyr1166) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB IF

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of IGF-1R only when phosphorylated at tyrosine 1165/tyrosine1166.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K) derived from Human IGF-1R .

基因/蛋白名称IGF-1R

修饰Phospho

别名 Insulin-like growth factor I receptor; CD221; IGF1R; kinase IGF1R;

数据库入口号Swiss-Prot: P08069
NCBI Protein: NP_000866.1

UniprotP08069

浓度1.0mg/ml

配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 200 95 kd
Western blotting: 1:500~1:1000
Immunofluorescence: 1:100~1:200

Western blot analysis of extracts from 293 cells untreated or treated with insulin using IGF-1R(Phospho-Tyr1165/Tyr1166) Antibody #11088.
Immunofluorescence staining of methanol-fixed MCF cells using IGF-1R(Phospho-Tyr1165/Tyr1166) Antibody #11088.
背景

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Li S, et al. (1994) J Biol Chem; 269(51): 32558-64.

如果您使用该产品11088发表了文章,请通知我们,让我们可以引用您的文献。

et al,PristimerIn attenuates cell proliferation of uveal melanoma cells by InhibitIng InsulIn-like growth factor-1 receptor and its downstream pathways. In J Cell Mol Med on 2019 Nov by Xie X, Xie S, et al..PMID:31508890, , (2019),
PMID: 31508890
et al,Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways.In Int J Mol Sci. On 2018 Sep 12 by Wang H, Su X et al..PMID: 30213025, , (2018),
PMID: 30213025
et al,H 2 O 2 Attenuates IGF-1R Tyrosine Phosphorylation and Its Survival Signaling Properties in Neuronal Cells via NR2B Containing NMDA Receptor.In Oncotarget on 2017 Jun 27 by Zhiwen Zeng, Dejun Wang,et al..PMID: 29029433, , (2017),
PMID: 29029433
et al,Glutamate Attenuates IGF-1 Receptor Tyrosine Phosphorylation in Mouse Brain: Possible Significance in Ischemic Brain Damage.In Neurosci Res on 2012 Dec by Chengming Sun, Qian Meng,et al..PMID:23085572, , (2012),
PMID: 23085572
5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

联系我们

Location :

南京市高新开发区星火路10号人才大厦C座

Phone :

400-9961-933
025-58868422

Email Address

techcn@signalwayantibody.com