产品详情
产品名称CD130 Antibody
来源种属Mouse
克隆性Monoclonal
克隆号B11-B9-A8
纯化ProG affinity purified
应用WB,IHC,ICC
种属反应性Hu
免疫原描述Recombinant protein
别名CD130 antibody
CD130 antigen antibody
CDw130 antibody
gp130 antibody
GP130 RAPS antibody
IL 6R beta antibody
IL-6 receptor subunit beta antibody
IL-6R subunit beta antibody
IL-6R-beta antibody
IL-6RB antibody
IL6 ST antibody
IL6RB_HUMAN antibody
IL6ST antibody
Interleukin 6 receptor subunit beta antibody
Interleukin receptor beta chain antibody
Interleukin-6 receptor subunit beta antibody
Interleukin-6 signal transducer antibody
Membrane glycoprotein 130 antibody
Membrane glycoprotein gp130 antibody
Oncostatin M receptor antibody
Oncostatin M receptor alpha subunit antibody
Oncostatin-M receptor subunit alpha antibody
数据库入口号Swiss-Prot#:P40189
计算分子量103 kDa
配方1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
保存Store at -20˚C
应用详情
WB: 1:500-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Western blot analysis of CD130 on CD130 recombinant protein using anti-CD130 antibody at 1/5,000 dilution.
Western blot analysis of CD130 on Raji cell (1) and mouse lung tissue (2) lysates using anti-CD130 antibody at 1/500 dilution.
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-CD130 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-CD130 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-CD130 antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-CD130 antibody. Counter stained with hematoxylin.
ICC staining CD130 (green) in HUVEC cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
ICC staining CD130 (green) in LOVO cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
背景
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition.
背景文献
1. Schutt A et al. gp130 activation is regulated by D2-D3 interdomain connectivity. Biochem. J. 450:487-496 (2013).
2. Waetzig GH et al. N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. J. Biol. Chem. 285:1781-1789 (2010).
Yes
