产品详情
产品名称C-C motif chemokine 2 Monoclonal Antibody
来源种属Mouse
克隆性Monoclonal
纯化protein G purifed
应用IHC
种属反应性Hu
特异性specific for human C-C motif chemokine 2 denatured and native forms
免疫原类型protein
免疫原描述Recombinant Human C-C motif chemokine 2
基因/蛋白名称C-C motif chemokine 2
别名Monocyte chemoattractant protein 1, Monocyte chemotactic and activating factor, Monocyte chemotactic protein 1, Monocyte secretory protein JE, Small-inducible cytokine A2, CCL2, MCP1, SCYA2
数据库入口号Swiss-Prot#: P13500
UniprotP13500
浓度1.0mg/mL
配方Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
保存Store at -20˚C
应用详情
Immunohistochemistry: 1:20 - 1:200
背景
Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. [1] "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)."Furutani Y., Nomura H., Notake M., Oyamada Y., Fukui T., Yamada M., Larsen C.G., Oppenheim J.J., Matsushima K.Biochem. Biophys. Res. Commun. 159:249-255(1989) [2] "The human homolog of the JE gene encodes a monocyte secretory protein."Rollins B.J., Stier P., Ernst T., Wong G.G.Mol. Cell. Biol. 9:4687-4695(1989) [3] "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE."Yoshimura T., Yuhki N., Moore S.K., Appella E., Lerman M.I., Leonard E.J.FEBS Lett. 244:487-493(1989)
背景文献
[1] "Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF)."Furutani Y., Nomura H., Notake M., Oyamada Y., Fukui T., Yamada M., Larsen C.G., Oppenheim J.J., Matsushima K.Biochem. Biophys. Res. Commun. 1
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