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位置: 首页 > 抗体 > Lys-63-specific deubiquitinase BRCC36 Polyclonal Antibody

Lys-63-specific deubiquitinase BRCC36 Polyclonal Antibody#42084

Lys-63-specific deubiquitinase BRCC36 Polyclonal Antibody
是否有货: 货期1周
产品总价:
产品详情

产品名称Lys-63-specific deubiquitinase BRCC36 Polyclonal Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Caprylic Acid Ammonium Sulfate Precipitation purified

应用WB

种属反应性Hu

特异性The antibody detects endogenous level of total Lys-63-specific deubiquitinase BRCC36 polyclonal antibody.

免疫原类型protein

免疫原描述Recombinant human Lys-63-specific deubiquitinase BRCC36 protein

基因/蛋白名称Lys-63-specific deubiquitinase BRCC36

别名BRCA1-A complex subunit BRCC36 BRCA1/BRCA2-containing complex subunit 3 BRCA1/BRCA2-containing complex subunit 36 BRISC complex subunit BRCC36 BRCC3 BRCC36, C6.1A, CXorf53

数据库入口号Swiss-Prot#: P46736

UniprotP46736

计算分子量36kd

配方Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

保存Store at -20˚C

应用详情
Western blotting: 1:500 - 1:1000
All lanes:Lys-63-specific deubiquitinase BRCC36 antibody at 2ug/ml+Hela whole cell lysate Secondary Goat polyclonal to Rabbit IgG at 1/15000 dilution Predicted band size:36KDa Observed band size:36KDa
背景
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.
背景文献
[1]Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene.Kenwrick S., Levinson B., Taylor S., Shapiro A., Gitschier J.Hum. Mol. Genet. 1:179-186(1992)[2]The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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