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位置: 首页 > 抗体 > NEDD4L Rabbit Polyclonal Antibody

NEDD4L Rabbit Polyclonal Antibody#55415

NEDD4L Rabbit Polyclonal Antibody
NEDD4L Rabbit Polyclonal Antibody
NEDD4L Rabbit Polyclonal Antibody
NEDD4L Rabbit Polyclonal Antibody
是否有货: Yes
产品总价:
产品详情

产品名称NEDD4L Rabbit Polyclonal Antibody

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Affinity purification

应用WB,IHC,IF

种属反应性Human,Mouse,Rat

免疫原描述Recombinant fusion protein of human NEDD4L (NP_056092.2).

别名NEDD4L;NEDD4-2;NEDD4.2;PVNH7;RSP5;hNEDD4-2

数据库入口号Swiss Prot:Q96PU5
GeneID:23327

UniprotQ96PU5

计算分子量96-111kDa

实际分子量113kDa

配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保存Store at -20˚C. Avoid freeze / thaw cycles.

应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Immunohistochemistry of paraffin-embedded rat kidney using NEDD4L at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate using NEDD4L at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using NEDD4L at 1:1000 dilution.
Immunofluorescence analysis of L929 cells using NEDD4L at dilution of 1:100. Blue: DAPI for nuclear staining.
背景
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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