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位置: 首页 > 重组兔单抗 > Bcr Rabbit mAb

Bcr Rabbit mAb#52722

评价
Recombinant
Bcr Rabbit mAb
Bcr Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称Bcr Rabbit mAb

来源种属Recombinant Rabbit

克隆性Monoclonal antibody

克隆号S02-6I0

亚型IgG

纯化Affinity Purified

应用WB IHC

种属反应性Human

免疫原描述A synthetic peptide of human Bcr

标记Unconjugated

修饰Unmodification

别名ALL; CML; PHL; BCR1; D22S11; D22S662

数据库入口号Swiss-Prot:P11274
GeneID:613

UniprotP11274

Gene ID613

计算分子量Calculated MW:143 kDa,Observed MW:160 kDa

配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

应用详情
WB: 1/2000 IHC: 1/20
Western blot detection of Bcr in A549,HL-60,U2OS,C6 cell lysates using Bcr Rabbit mAb(1:1000 diluted).Predicted band size:143kDa.Observed band size:160kDa.
Immunohistochemistry of Bcr in paraffin-embedded Human Brain using Bcr Rabbit mAb at dilution 1/50
背景
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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