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位置: 首页 > 重组兔单抗 > CD229 Rabbit mAb

CD229 Rabbit mAb#52735

评价
Recombinant
CD229 Rabbit mAb
是否有货: Yes
产品总价:
产品详情

产品名称CD229 Rabbit mAb

来源种属Recombinant Rabbit

克隆性Monoclonal antibody

克隆号S02-1I0

亚型IgG

纯化Affinity Purified

应用WB

种属反应性Human,Mouse,Rat

免疫原描述Recombinant protein of human CD229

标记Unconjugated

修饰Unmodification

别名hly9; mLY9; CD229; SLAMF3

数据库入口号Swiss-Prot:Q9HBG7
GeneID:4063

UniprotQ9HBG7

Gene ID4063

计算分子量Calculated MW:72 kDa,Observed MW:72 kDa

配方50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

保存Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.

应用详情
WB: 1/1000
Western blot detection of CD229 in Hela,A549,HL-60,U251 cell lysates using CD229 Rabbit mAb(1:1000 diluted).Predicted band size:72kDa.Observed band size:72kDa.
背景
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4+ T-cells. May negatively regulate the size of thymic innate CD8+ T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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