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位置: 首页 > 重组蛋白 > Recombinant Murine Interleukin-36 beta, 153a.a.

Recombinant Murine Interleukin-36 beta, 153a.a.#AP60170

Recombinant Murine Interleukin-36 beta, 153a.a.
是否有货: 3-5days
产品总价:
产品详情

产品名称Recombinant Murine Interleukin-36 beta, 153a.a.

来源种属Escherichia coli.

纯化> 97 % by SDS-PAGE and HPLC analyses.

生物活性Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 x105 IU/mg.

内毒素Less than 1 EU/ug of rMuIL-36尾, 153a.a. as determined by LAL method.

别名FIL1 eta, IL-1 eta, IL-1F8, IL-1H2

UniprotQ9D6Z6

Gene ID69677

计算分子量Approximately 17.4 kDa, a single non-glycosylated polypeptide chain containing 153 amino acids.

序列SSQSPRNYRV HDSQQMVWVL TGNTLTAVPA SNNVKPVILS LIACRDTEFQ DVKKGNLVFL GIKNRNLCFC CVEMEGKPTL QLKEVDIMNL YKERKAQKAF LFYHGIEGST SVFQSVLYPG WFIATSSIER QTIILTHQRG KLVNTNFYIE SEK

配方Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 5% trehalose.

保存Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - A minimum of 12 months from date of receipt, when stored at ≤-20 ˚C as supplied. - 1 month, 2 to 8 ˚C under sterile conditions after reconstitution. - 3 months, -20 to -70 ˚C under sterile conditions after reconstitution.

背景
Interleukin-36 is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. IL-36α, IL-36尾, and IL-36纬 (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36 beta is reported to be expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin and it can stimulate production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. IL-36 beta has two isoforms. IL-36尾2 contains one potential N-linked glycosylation site in its C-terminus, while IL -36尾 isoform 1 lacks potential N-linked glycosylation sites and four of the conserved 尾-strands. Within the IL-1 family, IL-36尾/IL-1F8 shares 30 %, 32 %, 37 %, 46 %, 34 %, 45 % and 28 % a.a. sequence identity with IL-1 ra, IL-1尾, IL-36Ra/IL-1F5, IL-36α/IL-1F6, IL-37/IL-1F7, IL-36纬/IL-1F9 and IL-1F10, respectively.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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