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位置: 首页 > 磷酸化抗体 > AML1 (Phospho-Ser303) Antibody

AML1 (Phospho-Ser303) Antibody#12003

AML1 (Phospho-Ser303) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称AML1 (Phospho-Ser303) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

应用WB

种属反应性Hu Ms Rt

特异性The antibody detects endogenous level of AML1 only when phosphorylated at Serine 303.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around phosphorylation site of serine 303 (T-A-F(p)-S-D) derived from Human AML1.

基因/蛋白名称AML1

修饰Phospho

别名CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1

数据库入口号Swiss-Prot#: Q01196;
NCBI Gene#: 861;
NCBI Protein#: NP_001001890.1

UniprotQ01196

实际分子量50kd

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20˚C/1 year

应用详情
Predicted MW: 50kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from JK cells using AML1 (Phospho-Ser303) Antibody #12003.The lane on the right is treated with the antigen-specific peptide.
背景
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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