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位置: 首页 > 抗体 > ABL1/2 (Ab-393/439) Antibody

ABL1/2 (Ab-393/439) Antibody#21530

ABL1/2 (Ab-393/439) Antibody
是否有货: 有货
产品总价:
产品详情

产品名称ABL1/2 (Ab-393/439) Antibody

来源种属Rabbit

克隆性Polyclonal

纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

应用WB

种属反应性Hu Ms

特异性The antibody detects endogenous levels of total ABL1/2 protein.

免疫原类型Peptide-KLH

免疫原描述Peptide sequence around aa.391~395/437~441(D-T-Y-T-A) derived from Human ABL1/2.

基因/蛋白名称ABL1/2

别名ABL; v-abl; c-ABL; p150; JTK7

数据库入口号Swiss-Prot: P00519 P42684
NCBI Protein: NP_005148.2 NP_001129472.1

浓度1.0mg/ml

配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

应用详情

Predicted MW: 135 210kd
Western blotting: 1:500~1:1000

Western blot analysis of extract from MCF-7, 293, HepG2 cells using ABL1/2 (Ab-393/439) Antibody #21530.
背景

Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Wang, J.Y. et al. (2000) Oncogene 19, 5643-5650.
Danial, N.N. et al. (2000) Oncogene 19, 2523-2531.
Brasher, B.B. et al. (2000) J. Biol. Chem. 275, 35631-35637.
Pluk, H. et al. (2002) Cell 108, 247-259.

如果您使用该产品21530发表了文章,请通知我们,让我们可以引用您的文献。

5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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