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位置: 首页 > 标记抗体 > Jak3 (Phospho-Tyr980 + Tyr981) Antibody Cy3 Conjugated

Jak3 (Phospho-Tyr980 + Tyr981) Antibody Cy3 Conjugated#C04547Cy3

是否有货: 货期15天
产品总价:
产品详情

产品名称Jak3 (Phospho-Tyr980 + Tyr981) Antibody Cy3 Conjugated

来源种属Rabbit

克隆性Polyclonal

亚型IgG

纯化Purified by Protein A.

应用IF(IHC-P)

种属反应性Hu Ms Rt

免疫原描述KLH conjugated synthetic phosphopeptide aa 971-990 1124 derived from human Jak3 around the phosphorylation site of Tyr980 981

标记Cy3

激发/发射波长512,550nm 570,615nm

基因/蛋白名称Jak3 Tyr980 + Tyr981

别名JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; Tyrosine-protein kinase JAK3; Janus kinase 3; Leukocyte janus kinase; JAK3

数据库入口号Swiss-Prot#:P52333
NCBI Gene ID:3718

细胞定位Cytoplasm, Cell membrane

浓度1mg ml

配方Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

保存 Store at 4C for 12 months.

应用详情
IF:1:50-200
背景
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.

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5

注释

应用

  • WB免疫印迹
  • IHC免疫组化
  • IF免疫荧光
  • ICC免疫细胞化学
  • FC流式细胞
  • IP免疫沉淀
  • E酶联免疫吸附法
  • DB免疫斑点法
  • ChIP染色质免疫沉淀
  • GICA胶体金免疫层析法
  • NC阴性对照

种属反应性

  • Hu
  • Ms小鼠
  • Rt大鼠
  • Dm果蝇
  • C线虫
  • Mk
  • Rb
  • B
  • D
  • P
  • Hm仓鼠
  • ChHm中国仓鼠
  • Chk

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