产品详情
产品名称MCL1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
应用WB
种属反应性Human;Rat
特异性The antibody detects endogenous level of total MCL1 protein.
免疫原类型Peptide-KLH
免疫原描述Peptide sequence around aa.148~152(N-N-T-S-T) derived from Human MCL1.
基因/蛋白名称MCL1
标记Unconjugated
别名TM; EAT; MCL1L; BCL2L3; mcl1/EAT
数据库入口号Swiss-Prot: Q07820
NCBI Protein: NP_068779.1
Uniprot
Q07820
浓度1.0mg/ml
配方Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
保存Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
应用详情
Predicted MW: 42kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from Raji, JK, HL-60 cells using MCL1 Antibody #21440.
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Bingle C.D., Craig R.W., Swales B.M., Singleton V., Zhou P., Whyte M.K.B.J. Biol. Chem. 275:22136-22146(2000)
Zhang D., Li F., Weidner D., Mnjoyan Z.H., Fujise K.J. Biol. Chem. 277:37430-37438(2002)
Leu J.I.-J., Dumont P., Hafey M., Murphy M.E., George D.L.Nat. Cell Biol. 6:443-450(2004)
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et al,miR-137 and miR-197 induce apoptosis and suppress tumorigenicity by targeting MCL-1 in multiple myeloma.In Clin Cancer Res on 2015 May 15 by Yijun Yang , Fei Li et al..PMID:25724519
, (2015),
PMID:
25724519
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