产品详情
产品名称ORAI1 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse
特异性This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
免疫原类型Peptide
免疫原描述Raised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1.
基因/蛋白名称ORAI1
标记Unconjugated
别名Transmembrane protein 142A, TMEM142A, Calcium release-activated calcium channel protein 1
数据库入口号Q96D31
Uniprot
Q96D31
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of ORAI1 in human ovary tissue lysate with ORAI1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/mL.
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.
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et al,Subchronic Exposure to Polystyrene Nanoplastics Disrupts Placental Development and Calcium Homeostasis: Insights from In Vivo and In Vitro Models
, (2025),
PMID:
40171975
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