产品详情
产品名称STEAP1 Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
应用WB;IHC;IF;ELISA
种属反应性Human;Mouse
特异性This STEAP1 antibody does not cross-react with other STEAP proteins.
免疫原描述The antiserum was produced against synthesized peptide derived from human STEAP1.
基因/蛋白名称STEAP1
标记Unconjugated
别名STEAP1 ; PRSS24 ; STEAP ; Metalloreductase STEAP1 ; Six-transmembrane epithelial antigen of prostate 1
数据库入口号Q9UHE8
Uniprot
Q9UHE8
Gene ID
26872
计算分子量40 kDa
浓度1mg/ml
配方Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
保存Store at -20℃/1 year
应用详情
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Immunohistochemistry of STEAP1 in human spleen tissue with STEAP1 antibody at 2.5 ug/mL.
Western Blot analysis of various cells using STEAP1 Polyclonal Antibody
Western blot analysis of lysate from A549, using STEAP1 antibody.
The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain; unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.
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et al,Prognostic Significance of Iron Metabolism Related Genes in Human Lung AdenocarcinomaInCancer Manag ResOn2023 Feb 22byPu Li?#?1,?Xiaoqiong Wu? et al..PMID: 36860893
, (2023),
PMID:
36860893
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