产品详情
产品名称Transthyretin Antibody
来源种属Chicken
克隆性Polyclonal
纯化Affinity chromatography purified via peptide column
应用ELISA WB IHC
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述Raised against a 17 amino acid peptide near the center of human Transthyretin.
基因/蛋白名称Transthyretin
标记Unconjugated
别名Transthyretin, TTR, PALB, TBPA, HsT2651
数据库入口号P02766
Uniprot
P02766
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
应用详情
Western blot analysis of Transthyretin in human lung tissue lysate with Transthyretin antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of Transthyretin in human lung tissue with Transthyretin antibody at 2.5 ug/mL.
Transthyretin is a tetrameric carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include familial amyloidotic polyneuropathy, euthyroid hyperthyroxinemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. It has also been suggested that Transthyretin plays an important role in the maintenance of normal cognitive processes during aging, neuropeptide processing and nerve regeneration. It has also been linked to several pathological conditions including Parkinson’s disease, schizophrenia, and depression.
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et al,PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth
, (2025),
PMID:
40132583
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