产品详情
产品名称Apaf-1 Monoclonal Antibody
克隆号mAb (Clone 5E11)
来源种属Mouse
克隆性Monoclonal
纯化Immunoaffinity chromotography purified IgG
应用ELISA IHC
种属反应性Human;Mouse;Rat
免疫原类型Peptide
免疫原描述A peptide corresponding to amino acids near the carboxy terminus of human Apaf1.
基因/蛋白名称Apaf-1
标记Unconjugated
别名Apaf-1 (5E11), Apoptotic protease activating factor 1
数据库入口号AAC51678
Uniprot
AAC51678
浓度1mg/ml
配方Supplied in PBS containing 0.02% sodium azide.
保存Can be stored at -20˚C, stable for one year.
应用详情
Immunohistochemistry of Apaf1 in K562 cells with Apaf1 antibody at 0.5 ug/ml.
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.
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et al,MAPK1 regulates platelet function and thrombus formation
, (2025),
PMID:
40447106
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