产品详情
产品名称ACO2 Antibody
来源种属Rabbit
克隆性Polyclonal
应用ELISA WB
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total ACO2 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to a region derived from 766-780 amino acids of human aconitase 2, mitochondrial
基因/蛋白名称ACO2
标记Unconjugated
别名Aconitase 2, mitochondrial, ICRD; ACONM
数据库入口号Genbank No.: NP_001089
Uniprot
NP_001089
配方Supplied at 0.9mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
保存Store at -20˚C/1 year
应用详情
Predicted MW: 85kd
ELISA: 1:2000-1:5000
Western blotting: 1:500-1:2000
Gel: 8%SDS-PAGE
Lane1: Mouse heart tissue lysate
Lane2: Hela cell lysate
Lysates: 40 ug per lane
Primary antibody: 1/400 dilution
Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Exposure time: 3 seconds
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification.?
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et al,Cuproptosis-related gene TMPO affects the healing of diabetic foot ulcers through TGF-β/Smad signaling pathway
, (2025),
PMID:
41321624
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