产品详情
产品名称PML Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB,IHC
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous level of total PML protein.
免疫原类型Recombinant Protein
免疫原描述Recombinant fusion protein of human PML (NP_150253.2).
基因/蛋白名称PML
标记Unconjugated
别名MYL;PP8675;RNF71;TRIM19;PML
数据库入口号Uniprot:P29590
GeneID:5371
Uniprot
P29590
Gene ID
5371
实际分子量70-130kDa
浓度1.0mg/ml
配方PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Western blot analysis of extracts of various cell lines, using PML antibody.
Immunohistochemistry of paraffin-embedded human appendix using PML antibody.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
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et al,Activation of bitter taste receptor TAS2R4 alleviates diabetic nephropathy in mice
, (2025),
PMID:
40228633
货期一周
