产品详情
产品名称GNAT3 Antibody
来源种属Rabbit
克隆性Polyclonal
纯化Antigen affinity purification.
应用WB;IHC;IF
种属反应性Human;Mouse;Rat
特异性The antibody detects endogenous levels of total GNAT3 protein.
免疫原类型Peptide
免疫原描述Synthetic peptide corresponding to residues near the N terminal of human guanine nucleotide binding protein, alpha transducing 3
基因/蛋白名称GNAT3
标记Unconjugated
别名GDCA
数据库入口号Swiss-Prot#: A8MTJ3
NCBI Gene ID: 346562
Gene Accssion: NP_001095856
Uniprot
A8MTJ3
浓度1.0 mg/ml
配方Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
保存Store at -20˚C
应用详情
WB 1:1000 - 1:5000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Gel: 8%SDS-PAGELysate: 10 μgLane 1-2: Mouse heart tissue, Mouse skin tissue lysatesPrimary antibody: 37600(GNAT3 Antibody) at dilution 1/1100 Secondary antibody: HRP-conjugated Goat anti rabbit IgG at 1/20000 dilutionExposure time: 2 seconds
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using 37600(GNAT3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image is immunofluorescence of NIH/3T3 cells using 37600 (GNAT3 Antibody) at dilution 1/50, followed by a further incubation with Cy3-conjugated Goat anti-Rabbit IgG at dilution 1/100 (Red). DAPI was used for nuclear staining (Blue).
Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein that in humans is encoded by the GNAT3 gene. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors.
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et al,DDTC-Cu (I) Nano-MOF Induces Ferroptosis by Targeting SLC7A11/GPX4 Signal in Colorectal Cancer
, (2025),
PMID:
40491359
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