产品详情
产品名称ABCA1 Rabbit Polyclonal Antibody
来源种属Rabbit
克隆性Polyclonal
亚型IgG
纯化Affinity purification
应用WB;IF
种属反应性Mouse
免疫原描述Recombinant fusion protein of human ABCA1 (NP_005493.2).
标记Unconjugated
别名ABCA1;ABC-1;ABC1;CERP;HDLDT1;TGD
数据库入口号Swiss Prot:O95477
GeneID:19
Uniprot
O95477
计算分子量254kDa
实际分子量270KDa
配方Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
保存Store at -20˚C. Avoid freeze / thaw cycles.
应用详情
WB 1:500 - 1:1000 IF/ICC 1:50 - 1:200
Western blot analysis of lysates from Mouse heart, using ABCA1 Rabbit pAb at 1:1000 dilution.
Immunofluorescence analysis of NIH/3T3 cells using ABCA1 Rabbit pAb at dilution of 1:100 (40x lens).
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
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et al,Probiotic membrane vesicles ameliorate atherosclerotic plaques by promoting lipid efflux and polarization of foamy macrophages
, (2025),
PMID:
40241138
Yes
